Epigenetics: A New Bridge between Nutrition and Health

Sang-Woon Choi, Simonetta Friso

Micronutrient Optimization Storage Trial Using Customized Vitamin & Mineral Replacement Therapy

Darrin L. Frye, MD, MPH ABAARM

Micronutrient Optimization Storage Trial Using Customized Vitamin & Mineral Replacement Therapy

Darrin L. Frye, MD, MPH ABAARM

Vitamin C: Intravenous Use by Complementary and Alternative Medicine Practitioners and Adverse Effects

Sebastian J. Padayatty, Andrew Y. Sun, Qi Chen, Michael Graham Espey, Jeanne Drisko, Mark Levine

Lack of Association Between the Trp719Arg Polymorphism in Kinesin-Like Protein-6 and Coronary Artery Disease in 19 Case-Control Studies

Themistocles L. Assimes, MD, PHD,1 Hilma Ho´lm, MD,2 Sekar Kathiresan, MD,3–6 Muredach P. Reilly, MB,7,8 Gudmar Thorleifsson, PHD,2 Benjamin F. Voight, PHD,4,5,9 Jeanette Erdmann, PHD,10 Christina Willenborg, MSC, 10,11 Dhananjay Vaidya, MBBS, PHD, MPH,12 Changchun Xie, PHD,13 Chris C. Patterson, PHD,14 Thomas M. Morgan, MD,15 Mary Susan Burnett, PHD,16 Mingyao Li, PHD,17 Mark A. Hlatky, MD,1 Joshua W. Knowles, MD, PHD,1 John R. Thompson, PHD,18 Devin Absher, PHD,19 Carlos Iribarren, MD, MPH, PHD,20 Alan Go, MD,20 Stephen P. Fortmann, MD,1 Stephen Sidney, MD, MPH,20 Neil Risch, PHD,21 Hua Tang, PHD,22 Richard M. Myers, PHD,19 Klaus Berger, MD,23 Monika Stoll, PHD,24 Svati H. Shah, MD, MHS,25 Gudmundur Thorgeirsson, MD, PHD,26,27 Karl Andersen, MD, PHD,26,27 Aki S. Havulinna, MSc,28 J. Enrique Herrera, MS,12 Nauder Faraday, MD,29 Yoonhee Kim, PHD,30 Brian G. Kral, MD, MPH,12 Rasika A. Mathias, ScD,12 Ingo Ruczinski, PHD,31 Bhoom Suktitipat, MD,32 Alexander F. Wilson, PHD,30 Lisa R. Yanek, MPH,12 Lewis C. Becker, MD,12 Patrick Linsel-Nitschke, MD,10 Wolfgang Lieb, MD,10 Inke R. König, PHD,11 Christian Hengstenberg, MD,33 Marcus Fischer, MD,33 Klaus Stark, PHD,33 Wibke Reinhard, MD,33 Janina Winogradow, MD,33 Martina Grassl, MD,33 Anika Grosshennig, MSC, 10,11 Michael Preuss, MSC, 10,11 Stefan Schreiber, MD,34 H-Erich Wichmann, MD,35–37 Christa Meisinger, MD, MPH,35,38 Jean Yee, BS,39,40 Yechiel Friedlander, PHD,41 Ron Do, MSc,42 James B. Meigs, MD, MPH,6,43 Gordon Williams, MD,6,44 David M. Nathan, MD,6,45 Calum A. MacRae, MD, PHD,3,6 Liming Qu, MS,17 Robert L. Wilensky, MD,7,8 William H. Matthai JR, MD,7 Atif N. Qasim, MD,8 Hakon Hakonarson, MD, PHD,46 Augusto D. Pichard, MD,16 Kenneth M. Kent, MD, PHD,16 Lowell Satler, MD,16 Joseph M. Lindsay, MD,16 Ron Waksman, MD,1,6 Christopher W. Knouff, MD, PHD,47 Dawn M. Waterworth, PHD,47 Max C. Walker, BSC, 47 Vincent E. Mooser, MD,47 Jaume Marrugat, MD, PHD,48 Gavin Lucas, PHD,48 Isaac Subirana, MSC, 48 Joan Sala, MD,49 Rafael Ramos, MD, PHD,50 Nicola Martinelli, MD,51 Oliviero Olivieri, MD, Elisabetta Trabetti, PHD,52 Giovanni Malerba, PHD,52 Pier Franco Pignatti, MD,52 Candace Guiducci, BS,5 Daniel Mirel, PHD,5 Melissa Parkin, BS,5 Joel N. Hirschhorn, MD, PHD,5,53 Rosanna Asselta, PHD,54 Stefano Duga, PHD,54 Kiran Musunuru, MD, PHD, MPH,3–6 Mark J. Daly, PHD,4–6 Shaun Purcell, PHD,4,5,55 Sandra Eifert, MD,56 Peter S. Braund, MSC, 57 Benjamin J. Wright, PHD,18 Anthony J. Balmforth, PHD,58 Stephen G. Ball, PHD,58 Myocardial Infarction Genetics Consortium, Wellcome Trust Case Control Consortium, Cardiogenics, Willem H. Ouwehand, MD, PHD,59,60 Panos Deloukas, PHD,60 Michael Scholz,61 Francois Cambien, MD,62 Andreas Huge, PHD,24 Thomas Scheffold, PHD,63 Veikko Salomaa, MD, PHD,28 Domenico Girelli, MD, PHD,51 Christopher B. Granger, MD,64 Leena Peltonen, MD, PHD,5,60,65 Pascal P. McKeown, MD,14 David Altshuler, MD, PHD,4–6,9,53 Olle Melander, MD, PHD,66 Joseph M. Devaney, PHD,16 Stephen E. Epstein, MD,16 Daniel J. Rader, MD,8,9 Roberto Elosua, MD, PHD,48 James C. Engert, PHD,42,67 Sonia S. Anand, MD, PHD,13 Alistair S. Hall, MD,58 Andreas Ziegler, PHD,11 Christopher J. O’Donnell, MD, MPH,3,6,68 John A. Spertus, MD, MPH, 69 David Siscovick, MD, MPH,39 Stephen M. Schwartz, PHD,39,40 Diane Becker, MPH, ScD,12 Unnur Thorsteinsdottir, PHD, Kari Stefansson, MD, PHD, Heribert Schunkert, MD, Nilesh J. Samani, MD, Thomas Quertermous, MD1

Nutriomes and nutrient arrays - the key to personalised nutrition for DNA damage prevention and cancer growth control

Michael F Fenech

Low and moderate, rather than high intensity strength exercise induces benefit regarding plasma lipid profile

Fabio S Lira, Alex S Yamashita, Marco C Uchida, Nelo E Zanchi, Bruno Gualano, Eivor Martins Jr, Erico C Caperuto, Marília Seelaender

Maternal micronutrient supplementation with zinc and β-carotene affects morbidity and immune function of infants during the first 6 months of life.

Wieringa FT, Dijkhuizen MA, Muhilal, Van der Meer JW

Inspiratory muscle strength is correlated with carnitine levels in type 2 diabetes.

Kiliçli F, Dökmetaş S, Candan F, Ozşahin S, Korkmaz S, Amasyali E, Fakioğlu K, Dal K, Acibucu F, Cakir I

Effect of physical activity on glutamine metabolism

Agostini F, Biolo G

Vitamin C: intravenous use by complementary and alternative medicine practitioners and adverse effects.

Padayatty SJ, Sun AY, Chen Q, Espey MG, Drisko J, Levine M

Plasma antioxidant concentration, not superoxide dismutase polymorphism, is associated with breast cancer risk in Korean women.

Kim MK, Ahn SH, Son BH, Sung MK

β-Carotene accumulation in 3T3-L1 adipocytes inhibits the elevation of reactive oxygen species and the suppression of genes related to insulin sensitivity induced by tumor necrosis factor-α.

Kameji H, Mochizuki K, Miyoshi N, Goda T

The multidisciplinary approach to the care of patients with intestinal failure at a tertiary care facility.

Rhoda KM, Parekh NR, Lennon E, Shay-Downer C, Quintini C, Steiger E, Kirby DF

Common genetic determinants of vitamin D insufficiency: a genome-wide association study.

Wang TJ, Zhang F, Richards JB, Kestenbaum B, van Meurs JB, Berry D, Kiel DP, Streeten EA, Ohlsson C, Koller DL, Peltonen L, Cooper JD, O'Reilly PF, Houston DK, Glazer NL, Vandenput L, Peacock M, Shi J, Rivadeneira F, McCarthy MI, Anneli P, de Boer IH, Mangino M, Kato B, Smyth DJ, Booth SL, Jacques PF, Burke GL, Goodarzi M, Cheung CL, Wolf M, Rice K, Goltzman D, Hidiroglou N, Ladouceur M, Wareham NJ, Hocking LJ, Hart D, Arden NK, Cooper C, Malik S, Fraser WD, Hartikainen AL, Zhai G, Macdonald HM, Forouhi NG, Loos RJ, Reid DM, Hakim A, Dennison E, Liu Y, Power C, Stevens HE, Jaana L, Vasan RS, Soranzo N, Bojunga J, Psaty BM, Lorentzon M, Foroud T, Harris TB, Hofman A, Jansson JO, Cauley JA, Uitterlinden AG, Gibson Q, Järvelin MR, Karasik D, Siscovick DS, Econs MJ, Kritchevsky SB, Florez JC, Todd JA, Dupuis J, Hyppönen E, Spector TD

The function of porcine PPARγ and dietary fish oil effect on the expression of lipid and glucose metabolism related genes.

Yu YH, Wu SC, Cheng WT, Mersmann HJ, Shen TL, Ding ST

Association of a functional polymorphism in the cholesteryl ester transfer protein (CETP) gene with memory decline and incidence of dementia.

Sanders AE, Wang C, Katz M, Derby CA, Barzilai N, Ozelius L, Lipton RB

Lack of Association Between the Trp719Arg Polymorphism in Kinesin-Like Protein-6 and Coronary Artery Disease in 19 Case-Control Studies.

Assimes TL, Hólm H, Kathiresan S, Reilly MP, Thorleifsson G, Voight BF, Erdmann J, Willenborg C, Vaidya D, Xie C, Patterson CC, Morgan TM, Burnett MS, Li M, Hlatky MA, Knowles JW, Thompson JR, Absher D, Iribarren C, Go A, Fortmann SP, Sidney S, Risch N, Tang H, Myers RM, Berger K, Stoll M, Shah SH, Thorgeirsson G, Andersen K, Havulinna AS, Herrera JE, Faraday N, Kim Y, Kral BG, Mathias RA, Ruczinski I, Suktitipat B, Wilson AF, Yanek LR, Becker LC, Linsel-Nitschke P, Lieb W, König IR, Hengstenberg C, Fischer M, Stark K, Reinhard W, Winogradow J, Grassl M, Grosshennig A, Preuss M, Schreiber S, Wichmann HE, Meisinger C, Yee J, Friedlander Y, Do R, Meigs JB, Williams G, Nathan DM, Macrae CA, Qu L, Wilensky RL, Matthai WH Jr, Qasim AN, Hakonarson H, Pichard AD, Kent KM, Satler L, Lindsay JM, Waksman R, Knouff CW, Waterworth DM, Walker MC, Mooser VE, Marrugat J, Lucas G, Subirana I, Sala J, Ramos R, Martinelli N, Olivieri O, Trabetti E, Malerba G, Pignatti PF, Guiducci C, Mirel D, Parkin M, Hirschhorn JN, Asselta R, Duga S, Musunuru K, Daly MJ, Purcell S, Eifert S, Braund PS, Wright BJ, Balmforth AJ, Ball SG

s disease in NSE/APPsw-transgenic mice.

Cho JY, Um HS, Kang EB, Cho IH, Kim CH, Cho JS, Hwang DY

Nutriomes and nutrient arrays - the key to personalised nutrition for DNA damage prevention and cancer growth control.

Fenech MF

A large prospective study of SEP15 genetic variation, interaction with plasma selenium levels, and prostate cancer risk and survival.

Penney KL, Schumacher FR, Li H, Kraft P, Morris JS, Kurth T, Mucci LA, Hunter DJ, Kantoff PW, Stampfer MJ, Ma J

Low and moderate, rather than high intensity strength exercise induces benefit regarding plasma lipid profile.

Lira FS, Yamashita AS, Uchida MC, Zanchi NE, Gualano B, Martins E Jr, Caperuto EC, Seelaender M

Hair loss in long-term or home parenteral nutrition: are micronutrient deficiencies to blame?

Daniells S, Hardy G

Suppression of tumor growth in xenograft model mice by programmed cell death 4 gene delivery using folate-PEG-baculovirus.

Kim YK, Kwon JT, Choi JY, Jiang HL, Arote R, Jere D, Je YH, Cho MH, Cho CS

Early supplementation of parenteral nutrition is capable of improving quality of life, chemotherapy-related toxicity and body composition in patients with advanced colorectal carcinoma undergoing palliative treatment: results from a prospective, randomized clinical trial.

Hasenberg T, Essenbreis M, Herold A, Post S, Shang E

Genetic effects on carotid intima-media thickness: systematic assessment and meta-analyses of candidate gene polymorphisms studied in more than 5000 subjects.

Paternoster L, Martinez-Gonzalez NA, Charleton R, Chung M, Lewis S, Sudlow CL

Genetics of homocysteine metabolism and associated disorders.

Brustolin S, Giugliani R, Félix TM

IL-2 and IL-10 gene polymorphisms are associated with respiratory tract infection and may modulate the effect of vitamin E on lower respiratory tract infections in elderly nursing home residents.

Belisle SE, Hamer DH, Leka LS, Dallal GE, Delgado-Lista J, Fine BC, Jacques PF, Ordovas JM, Meydani SN

Randomized trial of vitamin D supplementation to prevent seasonal influenza A in schoolchildren.

Urashima M, Segawa T, Okazaki M, Kurihara M, Wada Y, Ida H

Genetic variation at the SLC23A1 locus is associated with circulating concentrations of L-ascorbic acid (vitamin C): evidence from 5 independent studies with >15,000 participants.

Timpson NJ, Forouhi NG, Brion MJ, Harbord RM, Cook DG, Johnson P, McConnachie A, Morris RW, Rodriguez S, Luan J, Ebrahim S, Padmanabhan S, Watt G, Bruckdorfer KR, Wareham NJ, Whincup PH, Chanock S, Sattar N, Lawlor DA, Smith GD

Dietary choline requirements of women: effects of estrogen and genetic variation.

Fischer LM, da Costa KA, Kwock L, Galanko J, Zeisel SH

Dietary reference values of individual micronutrients and nutriomes for genome damage prevention: current status and a road map to the future.

Fenech MF

Micronutrient Optimization Storage Trial Using Customized Vitamin & Mineral Replacement Therapy

Darrin L. Frye, MD, MPH ABAARM

Case Study of a 49 year old white male with family history of ALZHEIMER’S DISEASE

s disease in NSE/APPsw-transgenic mice.

Cho JY, Um HS, Kang EB, Cho IH, Kim CH, Cho JS, Hwang DY

Supplementation of polyunsaturated fatty acids, magnesium and zinc in children seeking medical advice for attention-deficit/hyperactivity problems - an observational cohort study

Michael Huss, Andreas Völp, Manuela Stauss-Grabo

Supplementation of polyunsaturated fatty acids, magnesium and zinc in children seeking medical advice for attention-deficit/hyperactivity problems-an observational cohort study.

Huss M, Völp A, Stauss-Grabo M

Treatment of erectile dysfunction due to C677T mutation of the MTHFR gene with vitamin B6 and folic acid in patients non responders to PDE5i.

Lombardo F, Tsamatropoulos P, Piroli E, Culasso F, Jannini EA, Dondero F, Lenzi A, Gandini L

A multifaceted approach to maximize erectile function and vascular health.

Meldrum DR, Gambone JC, Morris MA, Ignarro LJ

Docosahexaenoic acid supplementation of primary rat hippocampal neurons attenuates the neurotoxicity induced by aggregated amyloid beta protein(42) and up-regulates cytoskeletal protein expression.

Wang PY, Chen JJ, Su HM

Docosahexaenoic acid supplementation and cognitive decline in Alzheimer disease: a randomized trial.

Quinn JF, Raman R, Thomas RG, Yurko-Mauro K, Nelson EB, Van Dyck C, Galvin JE, Emond J, Jack CR Jr, Weiner M, Shinto L, Aisen PS

Long-chain omega-3 fatty acids for indicated prevention of psychotic disorders: a randomized, placebo-controlled trial.

Amminger GP, Schäfer MR, Papageorgiou K, Klier CM, Cotton SM, Harrigan SM, Mackinnon A, McGorry PD, Berger GE

Detection of increased scyllo-inositol in brain with magnetic resonance spectroscopy after dietary supplementation in Alzheimer's disease mouse models

Choi JK, Carreras I, Dedeoglu A, Jenkins BG

Lipid alterations in lipid rafts from Alzheimer's disease human brain cortex

Martín V, Fabelo N, Santpere G, Puig B, Marín R, Ferrer I, Díaz M

High plasma levels of vitamin E forms and reduced Alzheimer's disease risk in advanced age

Mangialasche F, Kivipelto M, Mecocci P, Rizzuto D, Palmer K, Winblad B, Fratiglioni L

Amyloid-beta fibrillogenesis: structural insight and therapeutic intervention.

Dasilva KA, Shaw JE, McLaurin J

s disease: a review of controversial and clinical experiences.

Usoro OB, Mousa SA

Dietary antioxidants and long-term risk of dementia

Devore EE, Grodstein F, van Rooij FJ, Hofman A, Stampfer MJ, Witteman JC, Breteler MM

Significance of long-chain polyunsaturated fatty acids (PUFAs) for the development and behaviour of children.

Schuchardt JP, Huss M, Stauss-Grabo M, Hahn A

Neurochemical alterations in women with borderline personality disorder and comorbid attention-deficit hyperactivity disorder.

Rüsch N, Boeker M, Büchert M, Glauche V, Bohrmann C, Ebert D, Lieb K, Hennig J, Tebartz Van Elst L

Low serum levels of 25-hydroxyvitamin D (25-OHD) among psychiatric out-patients in Sweden: Relations with season, age, ethnic origin and psychiatric diagnosis.

Humble MB, Gustafsson S, Bejerot S

The Impact of Polyunsaturated Fatty Acids in Reducing Child Attention Deficit and Hyperactivity Disorders.

Transler C, Eilander A, Mitchell S, van de Meer N

Effect of Micronutrients on Behavior and Mood in Adults With ADHD: Evidence From an 8-Week Open Label Trial With Natural Extension

Rucklidge J, Taylor M, Whitehead K

Effects of zinc and ferritin levels on parent and teacher reported symptom scores in attention deficit hyperactivity disorder.

Oner O, Oner P, Bozkurt OH, Odabas E, Keser N, Karadag H, Kizilgün M

EPA supplementation improves teacher rated behaviour and oppositional symptoms in children with ADHD.

Gustafsson PA, Birberg-Thornberg U, Duchén K, Landgren M, Malmberg K, Pelling H, Strandvik B, Karlsson T

An observational study of methionine-bound zinc with antioxidants for mild to moderate acne vulgaris

Sardana K, Garg VK

Lower maternal folate status in early pregnancy is associated with childhood hyperactivity and peer problems in offspring.

Schlotz W, Jones A, Phillips DI, Gale CR, Robinson SM, Godfrey KM

Genetics of homocysteine metabolism and associated disorders

S. Brustolin, R. Giugliani, T.M. Félix

Association of a functional polymorphism in the cholesteryl ester transfer protein (CETP) gene with memory decline and incidence of dementia.

Sanders AE, Wang C, Katz M, Derby CA, Barzilai N, Ozelius L, Lipton RB

Case Study of a 39 year old female with SEVERE GERD, FIBROMYALGIA, RECURRENT ALLERGIES & SINUS INFECTIONS

Hypomagnesaemia due to proton-pump inhibitor therapy: a clinical case series.

Mackay JD, Bladon PT

Possible Increased Risk of Bone Fractures With Certain Antacid Drugs

Food and Drug Administration (FDA)

Hypomagnesaemia due to proton-pump inhibitor therapy: a clinical case series

J.D. MACKAY, P.T. BLADON

Fish consumption and prostate cancer risk: a review and meta-analysis.

Szymanski KM, Wheeler DC, Mucci LA

Acetyl-L-Carnitine Monograph

Aspirin Intake and Survival After Breast Cancer

Holmes MD, Chen WY, Li L, Hertzmark E, Spiegelman D, Hankinson SE

Case Study

Case Study

Case Study

Case Study